Anti-RGS14 antibody

$275.00

  • Model: PAab07266
  • 50 Units in Stock
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Anti-RGS14 antibody

Product Name Anti-RGS14 antibody

Catalog No PAab07266

Packing 100ug

Form liquid

Alternative Name

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)- mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal- based learning and memory.

Immunogen regulator of G-protein signaling 14

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IP

Recommended dilution

IHC use

WB use

Protein Information

Gene ID10636

Uniprot ID O43566

Calculated MW

location

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