Anti-RRP8 antibody
Product Name Anti-RRP8 antibody
Catalog No PAab07501
Packing 100ug
Form liquid
Alternative Name KIAA0409 antibody, NML
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Immunogen ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Specificity Human,Mouse ,Rat
Tested Application ELISA,WB,IF,IHC
Recommended dilution
IHC use
Immunohistochemistry of paraffin-embedded human skin usingRRP8 antibody at dilution of 1:100
WB use
human brain tissue were subjected to SDS PAGE followed by western blot with PAab07501(RRP8 antibody) at dilution of 1:1500
Protein Information
Gene ID23378
Uniprot ID O43159
Calculated MW
location