Anti-STAT1 antibody

$275.00

  • Model: LSMab09985
  • 100 Units in Stock
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Anti-STAT1 antibody

Product Information
Catalog No.:    LSMab09985
Size:    100μg
Form:    liquid
Purification:    Immunogen affinity purified
Purity:    ≥95% as determined by SDS-PAGE
Host:    Rabbit
IsoType:    IgG
Storage:    PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Background
Signal transducer and transcription activator that mediates cellular responses to interferons(IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN(IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases(TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of IFN-stimulated genes(ISG), which drive the cell in an antiviral state. In response to type II IFN(IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor(GAF), migrates into the nucleus and binds to the IFN gamma activated sequence(GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Immunogen information
Immunogen:    signal transducer and activator of transcription 1, 91kDa
Synonyms:    ISGF 3, STAT1, STAT91
Calculated MW:    84 kDa
Uniprot ID :    P42224

Application
Specificity:    Human, Rat; other species are not tested. Please decide the specificity by homology
Tested Application:    ELISA, WB, IHC
Recommended dilution:    WB: 1:500-1:2000; IHC: 1:50-1:500
Image:

     


Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using LSMab09985(STAT1 Antibody) at dilution of 1:200
 


Rat liver tissue were subjected to SDS PAGE followed by western blot with LSMab09985(STAT1 antibody) at dilution of 1:1000


 

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