Anti-STT3B antibody

$275.00

  • Model: PAab08356
  • 50 Units in Stock
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Anti-STT3B antibody

 

Product Name Anti-STT3B antibody

Catalog No PAab08356

Packing 100ug

Form liquid

Alternative Name

SIMP, STT3 B, STT3B,STT3, subunit of the oligosaccharyltransferase complex, homolog B

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL- TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.

Immunogen STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB

Recommended dilution WB: 1:1000-1:4000; IHC: 1:50-1:500

IHC use

Immunohistochemistry of paraffin-embedded human liver tissue slide using anti-STT3B Antibody at dilution of 1:200.

WB use

Human brain tissue were subjected to SDS PAGE followed by western blot with anti-STT3B Antibody at dilution of 1:2000.

Protein Information

Gene ID   201595

Uniprot ID Q8TCJ2

Calculated MW  94 kDa

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