Anti-TRIM33 antibody

Product Name Anti-TRIM33 antibody

Catalog No PAab08981

Packing 100ug

Form liquid

Alternative Name Ectodermin homolog antibody, FLJ32925 antibody, KIAA1113 antibody, Protein Rfg7 antibody, PTC7 antibody, RET fused gene 7 protein antibody, RFG7 antibody, TF1G antibody, TIF1 gamma antibody, TIF1G antibody, TIF1GAMMA antibody, TIFGAMMA antibody, TRIM33 antibody, tripartite motif containing 33

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).

Immunogen tripartite motif-containing 33

Specificity Human

Tested Application ELISA,WB

Recommended dilution WB:1:200-1:2000

IHC use

WB use

COLO 320 cells were subjected to SDS PAGE followed by western blot with PAab08981(TRIM33 antibody) at dilution of 1:500

Protein Information

Gene ID51592

Uniprot ID Q9UPN9

Calculated MW 120kDa,Observed 150kDa

location