Anti-Tuberin-Specific antibody

Product Name Anti-Tuberin-Specific antibody

Catalog No PAab09101

Packing 100ug

Form liquid

Alternative Name FLJ43106 antibody, LAM antibody, TSC2 antibody, TSC4 antibody, Tuberin antibody, tuberous sclerosis 2 antibody, Tuberous sclerosis 2 protein

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

TSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.

Immunogen tuberous sclerosis 2

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IF,IHC

Recommended dilution WB:1:200-1:2000;IHC:1:20-1:200