Anti-VAMP8 antibody

Product Name Anti-VAMP8 antibody

Catalog No PAab09365

Packing 100ug

Form liquid

Alternative Name EDB antibody, Endobrevin antibody, VAMP 8 antibody, VAMP8

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity).

Immunogen vesicle-associated membrane protein 8 (endobrevin)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB

Recommended dilution WB :1:200-1:1000

IHC use

WB use

HL-60 cells were subjected to SDS PAGE followed by western blot with PAab09365( VAMP8 Antibody) at dilution of 1:300

Protein Information

Gene ID8673

Uniprot ID Q9BV40

Calculated MW 15kDa

location