Anti-VEGF antibody

$275.00

  • Model: PAab09391
  • 50 Units in Stock
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Anti-VEGF antibody

Product Name Anti-VEGF antibody

Catalog No PAab09391

Packing 100ug

Form liquid

Alternative Name L VEGFA antibody, MVCD1 antibody, Vascular permeability factor antibody, VEGF antibody, VEGF A antibody, VEGFA antibody, VPF

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

VEGFA, also named as VEGF or VPF, belongs to the PDGF/VEGF growth factor family. It is a growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. VEGFA induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1). VEGFA has 13 isoforms with MW 16kd to 45kd. Some isoforms has homodimer form, such as VEGFA189(38kd), VEFGA110(34kd). VEGFA is a 34kd to 42kd, dimeric, disulfide-bound glycoprotein. VEGF-A exists in at least seven homodimeric isoforms. The monomers consist of 121, 145, 148, 165, 183, 189, or 206 amino acids(PMID:15602010 ). This antibody can recognize all the isoforms of VEFGA.

Immunogen vascular endothelial growth factor A

Specificity Human,Mouse ,Rat

Tested Application ELISA,IHC,IF,IP,WB

Recommended dilution WB :1:200-1:2000;IP:1:200-1:2000;IF:1:10-1:100;IHC:1:50-1:500

IHC use

Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using VEGFA Antibody at dilution of 1:200

WB use

PC-3 cells were subjected to SDS PAGE followed by western blot with PAab09391(VEGFA antibody) at dilution of 1:800

Protein Information

Gene ID7422

Uniprot ID P15692

Calculated MW 27kDa

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