Anti-VPS26B antibody

$275.00

  • Model: PAab09433
  • 50 Units in Stock
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Anti-VPS26B antibody

Product Name Anti-VPS26B antibody

Catalog No PAab09433

Packing 100ug

Form liquid

Alternative Name Pep8b antibody, Vesicle protein sorting 26B antibody, VPS26B

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

Immunogen vacuolar protein sorting 26 homolog B (S. pombe)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB

Recommended dilution WB :1:500-1:5000

IHC use

WB use

human brain tissue were subjected to SDS PAGE followed by western blot with PAab09433(VPS26B antibody) at dilution of 1:1000

Protein Information

Gene ID112936

Uniprot ID Q4G0F5

Calculated MW 39kDa

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