Anti-VPS39 antibody

$300.00

  • Model: PAab09441
  • 50 Units in Stock
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Anti-VPS39 antibody

Product Name Anti-VPS39 antibody

Catalog No PAab09441

Packing 100ug

Form liquid

Alternative Name FLJ21681 antibody, FLJ46546 antibody, hVam6p antibody, KIAA0770 antibody, TLP antibody, VAM6 antibody, Vam6/Vps39 like protein antibody, VPS39

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes (PubMed:11448994, PubMed:23351085, PubMed:23167963). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203).

Immunogen vacuolar protein sorting 39 homolog (S. cerevisiae)

Specificity Human

Tested Application ELISA

Recommended dilution IP:1:200-1:1000

IHC use

WB use

Protein Information

Gene ID23339

Uniprot ID Q96JC1

Calculated MW 102kDa

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