Anti-VPS4B antibody

$275.00

  • Model: PAab09446
  • 50 Units in Stock
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Anti-VPS4B antibody

Product Name Anti-VPS4B antibody

Catalog No PAab09446

Packing 100ug

Form liquid

Alternative Name MIG1 antibody, Protein SKD1 antibody, SKD1 antibody, VPS4 2 antibody, VPS42 antibody, VPS4B

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Immunogen vacuolar protein sorting 4 homolog B (S. cerevisiae)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IF,IP

Recommended dilution WB :1:500-1:5000

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