Anti-VWF, VWFpp antibody


  • Model: PAab09466
  • 50 Units in Stock
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Anti-VWF, VWFpp antibody

Product Name Anti-VWF, VWFpp antibody

Catalog No PAab09466

Packing 100ug

Form liquid

Alternative Name F8VWF antibody, von Willebrand antigen II antibody, von Willebrand factor antibody, VWD antibody, VWF

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Von Willebrand factor (vWF) is a large multimeric glycoprotein that is crucial to the hemostasis process. It supports platelet adhesion and carries factor VIII (FVIII). Deficiency of vWF results in von Willebrand disease (vWD), a common inherited bleeding disorder. The pre-pro-vWF is comprised of 2,813 amino acids (aa) which encompass a 22-aa signal peptide, a 741-aa large propeptide (vWF propeptide, vWFpp, also called von Willebrand antigen II) and 2,050 aa making up the mature vWF. The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules. This antibody raised against the N-terminal region (residues 56-256 aa) of pre-pro-vWF recognizes von Willebrand antigen 2 (75-83 kDa) and pro-vWF (309-320 kDa). (PMID: 9759493; 12067899; 22452980; 8874191)

Immunogen von Willebrand factor

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC

Recommended dilution WB : 1:200-1:2000

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