Anti-WIPI1 antibody

$300.00

  • Model: PAab09512
  • 50 Units in Stock
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Anti-WIPI1 antibody

Product Name Anti-WIPI1 antibody

Catalog No PAab09512

Packing 100ug

Form liquid

Alternative Name ATG18 antibody, Atg18 protein homolog antibody, FLJ10055 antibody, WIPI 1 antibody, WIPI 49 kDa antibody, WIPI1 antibody, WIPI49

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.

Immunogen WD repeat domain, phosphoinositide interacting 1

Specificity Human, Mouse

Tested Application ELISA,WB

Recommended dilution WB : 1:500-1:5000

IHC use

WB use

SW 1990 cells were subjected to SDS PAGE followed by western blot with PAab09512( WIPI1 Antibody) at dilution of 1:1000

Protein Information

Gene ID55062

Uniprot ID Q5MNZ9

Calculated MW 49kDa

location

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