Anti-WWP2 antibody

$300.00

  • Model: PAab09535
  • 50 Units in Stock
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Anti-WWP2 antibody

Product Name Anti-WWP2 antibody

Catalog No PAab09535

Packing 100ug

Form liquid

Alternative Name AIP2 antibody, WW domain containing protein 2 antibody, WWP2 antibody, WWp2 like

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Immunogen WW domain containing E3 ubiquitin protein ligase 2

Specificity Human, Mouse

Tested Application ELISA,WB,IHC

Recommended dilution WB:1:200-1:2000;IHC:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human pancreas cancer usingWWP2 antibody at dilution of 1:100

WB use

mouse liver tissue were subjected to SDS PAGE followed by western blot with PAab09535(WWP2 antibody) at dilution of 1:500

Protein Information

Gene ID11060

Uniprot ID O00308

Calculated MW 99kDa,Observed 120kDa

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