Anti-XRCC5/Ku80 antibody

$300.00

  • Model: PAab09555
  • 50 Units in Stock
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Anti-XRCC5/Ku80 antibody

Product Name Anti-XRCC5/Ku80 antibody

Catalog No PAab09555

Packing 100ug

Form liquid

Alternative Name 86 kDa subunit of Ku antigen antibody, CTC85 antibody, CTCBF antibody, DNA repair protein XRCC5 antibody, FLJ39089 antibody, G22P2 antibody, KARP 1 antibody, KARP1 antibody, Ku80 antibody, Ku86 antibody, KUB2 antibody, NFIV antibody, Nuclear factor IV antibody, Thyroid lupus autoantigen antibody, TLAA antibody, XRCC5

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

There are at least two pathways for eukaryotes to repair DNA double-strand breaks: homologous recombination and nonhomologous end joining(NHEJ). The core NHEJ machinery includes XRCC4, DNA ligase IV and the DNA-dependent protein kinase complex, which consists of the DNA end-binding XRCC5/XRCC6 heterodimer and the catalytic subunit PRKDC. The heterdimer of XRCC5/XRCC6 enhanced teh affinity of the catalytic subunit PRKDC to DNA by 100-fold. Once the XRCC5/6 dimer association with NAA15, it can bind to the osteocalcin promoter and activate osteocalcin expression. The XRCC5/6 dimer acts as a negative regulator of transcription when together with APEX1. Some publised papers indicated that the MW of XRCC5 is 86kDa, while more papers suggested that XRCC5 is a 80kDa protein, as it was firstly introducted in publication. Thus, Ku80 and Ku86 are the same protein.

Immunogen X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Specificity Human

Tested Application ELISA,WB,IHC,IF,IP

Recommended dilution WB:1:500-1:5000;IHC:1:20-1:200;IF:1:20-1:200;IP:1:500-1:5000

IHC use

Immunohistochemistry of paraffin-embedded human colon cancer usingXRCC5 antibody at dilution of 1:100

WB use

HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09555(XRCC5 antibody) at dilution of 1:1000

Protein Information

Gene ID7520

Uniprot ID P13010

Calculated MW 83kDa

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