Anti-YTHDC1 antibody

$275.00

  • Model: PAab09571
  • 50 Units in Stock
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Anti-YTHDC1 antibody

Product Name Anti-YTHDC1 antibody

Catalog No PAab09571

Packing 100ug

Form liquid

Alternative Name KIAA1966 antibody, Putative splicing factor YT521 antibody, YT521 antibody, YT521 B antibody, YTH domain containing 1 antibody, YTHDC1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A- containing mRNAs and promotes recruitment of SRSF3 to its mRNA- binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).

Immunogen YTH domain containing 1

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB

Recommended dilution WB : 1:200-1:1000

IHC use

WB use

MCF-7 cells were subjected to SDS PAGE followed by western blot with PAab09571( YTHDC1 Antibody) at dilution of 1:300

Protein Information

Gene ID91746

Uniprot ID Q96MU7

Calculated MW 85kDa,Observed 110kDa

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