Anti-YTHDF2 antibody


  • Model: PAab09573
  • 50 Units in Stock
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Anti-YTHDF2 antibody

Product Name Anti-YTHDF2 antibody

Catalog No PAab09573

Packing 100ug

Form liquid

Alternative Name CLL associated antigen KW 14 antibody, HGRG8 antibody, NY REN 2 antibody, YTH domain family protein 2 antibody, YTH domain family antibody, member 2 antibody, YTHDF2

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P- bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103).

Immunogen YTH domain family, member 2

Specificity Human

Tested Application ELISA,WB,IF,IHC

Recommended dilution WB:1:500-1:5000;IF:1:10-1:100;IP:1:200-1:2000;IHC:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human testis tissue slide using YTHDF2 Antibody at dilution of 1:50

WB use

Jurkat cells were subjected to SDS PAGE followed by western blot with PAab09573( YTHDF2 Antibody) at dilution of 1:1000

Protein Information

Gene ID51441

Uniprot ID Q9Y5A9

Calculated MW 62kDa


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