Anti-ZAK antibody

$275.00

  • Model: PAab09581
  • 50 Units in Stock
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Anti-ZAK antibody

Product Name Anti-ZAK antibody

Catalog No PAab09581

Packing 100ug

Form liquid

Alternative Name AZK antibody, HCCS 4 antibody, MLK related kinase antibody, MLK7 antibody, mlklak antibody, MLT antibody, MLTK antibody, MRK antibody, ZAK

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). Isoform 1: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).

Immunogen sterile alpha motif and leucine zipper containing kinase AZK

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC,IF

Recommended dilution WB:1:500-1:5000;IHC:1:20-1:200;IF:1:10-1:100

IHC use

Immunohistochemistry of paraffin-embedded human liver tissue slide using ZAK Antibody at dilution of 1:50

WB use

HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09581(ZAK antibody) at dilution of 1:500

Protein Information

Gene ID51776

Uniprot ID Q9NYL2

Calculated MW 91kDa,Observed 52kDa

location

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