Anti-ZBP1 antibody

$300.00

  • Model: PAab09586
  • 50 Units in Stock
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Anti-ZBP1 antibody

Product Name Anti-ZBP1 antibody

Catalog No PAab09586

Packing 100ug

Form liquid

Alternative Name ZBP1 antibody, C20orf183 antibody, DLM1 antibody, Z DNA binding protein 1 antibody, DLM 1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).

Immunogen Z-DNA binding protein 1

Specificity Human

Tested Application ELISA,WB,IHC

Recommended dilution WB:1:500-1:5000;IHC:1:20-1:200

IHC use

Immunohistochemistry of paraffin-embedded human liver cancer usingZBP1 antibody at dilution of 1:50

WB use

Jurkat cells were subjected to SDS PAGE followed by western blot with PAab09586(ZBP1 antibody) at dilution of 1:400

Protein Information

Gene ID81030

Uniprot ID Q9H171

Calculated MW 49kDa,Observed 66kDa

location

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