Anti-ZC3HAV1 antibody

$275.00

  • Model: PAab09606
  • 50 Units in Stock
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Anti-ZC3HAV1 antibody

Product Name Anti-ZC3HAV1 antibody

Catalog No PAab09606

Packing 100ug

Form liquid

Alternative Name DKFZp686F2052 antibody, DKFZp686H1869 antibody, DKFZp686O19171 antibody, FLB6421 antibody, FLJ13288 antibody, ZAP antibody, ZC3H2 antibody, ZC3HAV1 antibody, ZC3HDC2 antibody, Zinc finger antiviral protein

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).

Immunogen zinc finger CCCH-type, antiviral 1

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IHC

Recommended dilution WB:1:1000-1:10000;IHC:1:20-1:200;IP:1:1000-1:10000

IHC use

Immunohistochemistry of paraffin-embedded human testis tissue slide using ZC3HAV1 Antibody at dilution of 1:50

WB use

HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab09606( ZC3HAV1 Antibody) at dilution of 1:4000

Protein Information

Gene ID56829

Uniprot ID Q7Z2W4

Calculated MW 101kDa

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