Anti-ZCCHC11 antibody


  • Model: PAab09609
  • 50 Units in Stock
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Anti-ZCCHC11 antibody

Product Name Anti-ZCCHC11 antibody

Catalog No PAab09609

Packing 100ug

Form liquid

Alternative Name KIAA0191 antibody, PAPD3 antibody, Terminal uridylyltransferase 4 antibody, TUT4 antibody, TUTase 4 antibody, ZCCHC11

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Immunogen zinc finger, CCHC domain containing 11

Specificity Human, Mouse

Tested Application ELISA,WB,IF,IP

Recommended dilution WB : 1:200-1:2000;IP:1:500-1:5000;IF:1:20-1:200

IHC use

WB use

MCF7 cells were subjected to SDS PAGE followed by western blot with PAab09609(ZCCHC11 antibody) at dilution of 1:500

Protein Information

Gene ID23318

Uniprot ID Q5TAX3

Calculated MW 185kDa


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