Anti-ZCCHC6 antibody

$275.00

  • Model: PAab09611
  • 50 Units in Stock
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Anti-ZCCHC6 antibody

Product Name Anti-ZCCHC6 antibody

Catalog No PAab09611

Packing 100ug

Form liquid

Alternative Name DKFZp666B142 antibody, DKFZp686C11112 antibody, DKFZp686F119 antibody, DKFZp686I1269 antibody, HS2 antibody, KIAA1711 antibody, PAPD6 antibody, Terminal uridylyltransferase 7 antibody, TUT7 antibody, TUTase 7 antibody, ZCCHC6

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Immunogen zinc finger, CCHC domain containing 6

Specificity Human, Mouse ,Rat

Tested Application ELISA,WB,IP

Recommended dilution WB : 1:500-1:5000;IP:1:500-1:5000

IHC use

WB use

PC-3 cells were subjected to SDS PAGE followed by western blot with PAab09611( ZCCHC6 Antibody) at dilution of 1:1000

Protein Information

Gene ID79670

Uniprot ID Q5VYS8

Calculated MW 171kDa

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