Anti-ZO-1 antibody

$300.00

  • Model: PAab09750
  • 50 Units in Stock
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Anti-ZO-1 antibody

 

Product Name Anti-ZO-1 antibody

Catalog No PAab09750

Packing 100ug

Form liquid

Alternative Name Tight junction protein 1 antibody, Tight junction protein ZO 1 antibody, TJP1 antibody, ZO 1 antibody, ZO1 antibody, ZO-1 antibody, Zona occludens protein 1 antibody, Zonula occludens protein 1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Tight junction (or zonula occludens) form the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium (PMID: 20066090). ZO-1 (also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells (PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin (PMID: 17418867). ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs (MAGUKs). It is a pivotal tight junction protein and may be involved in signalling mechanisms regulating cell proliferation and differentiation (PMID: 22782886).

Immunogen tight junction protein 1 (zona occludens 1)

Specificity Human

Tested Application ELISA,IF

Recommended dilution IF:1:20-1:200

1X10^6 MCF-7 cells were stained with 0.2ug ZO1 antibody (red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L) with dilution 1:1000

Protein Information

Gene ID7082

Uniprot ID Q07157

Calculated MW 195kDa

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