Anti-ZRANB3 antibody

$300.00

  • Model: PAab09756
  • 50 Units in Stock
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Anti-ZRANB3 antibody

Product Name Anti-ZRANB3 antibody

Catalog No PAab09756

Packing 100ug

Form liquid

Alternative Name DNA annealing helicase and endonuclease ZRANB3 antibody,Annealing helicase 2 antibody,AH2

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Immunogen zinc finger, RAN-binding domain containing 3

Specificity Human

Tested Application ELISA,WB

Recommended dilution WB:1:200-1:2000;IF:1:20-1:200

IHC use

WB use

HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab09756( ZRANB3 Antibody) at dilution of 1:600

Protein Information

Gene ID84083

Uniprot ID Q5FWF4

Calculated MW 123kDa,observed 150kDa and 50kDa

location

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