CYP2E1 Antibody


  • Model: ABD6883
  • 50 Units in Stock
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CYP2E1 Antibody

Catalog  ABD6883    Packing 100ug

Reactivity with Human Mouse Rat

M.W.(Molecular Weight)  57kDa

Application  WB IHC 

 WB 1:500-1:2000 IHC 1:50-1:200

Western blot analysis of extracts of various celllines, using CYP2E1 antibody.

Western blot analysis of CYP2E1 expression in Mouse Liver lysate.

Purification: Immunogen affinity purified 

Specificity: CYP2E1 Antibody detects endogenous levels of total CYP2E1 

Immunogen: Recombinant proteinof human CYP2E1 

CYP2E1 Protein Information

Uniprot ID P05181

Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]

Function: Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.

Subcellular Location: Endoplasmic reticulum;Golgi apparatus;Mitochondrion

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