Polyclonal Antibody- Human HAS2

$400.00

  • Model: PA-RA-90002
  • 20 Units in Stock
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Polyclonal Antibody- Human HAS2 
FOR RESEARCH USE ONLY. 
PROUDUCT INFORMATION
 
Size: 0.2ml (200ug/ml)
Immunogen: Synthetic peptide-KLH
Ig type: Human IgG
 
BACKGROUND  
HAS1, HAS2 and HAS3 are HA Synthase proteins that synthesize HA (hyaluronan or hyaluronic acid). The extracellular matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds. The three HAS genes show distinct patterns of expression during development and their protein products play significantly different roles in the formation of the HA matrix. Both HAS1 and HAS2 synthesize high molecular-weight HA, whereas HAS3 produces lower molecular weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially regulated by various stimuli suggesting distinct functional roles of the three proteins. 
SPEFICITY    
Anti-HAS2 antibody is a rabbit polyclonal antibody raised against Human HAS2 . This antibody has been selected for its ability to recognize Human HAS2  in immunohistochemiscal staining, non cross-reactive with other members of the family. 
APPLICATION   Immunocytochemistry in formalin fixed cells:  1:100-500
                   Immunohistochemistry in formalin fixed frozen section:  1:100-500
Immunohistochemistry  in paraffin section:  1:50-200
Optimal working dilutions must be determined by end user.                                                                                                                                                             
CONTENTS     0.1M PBS, 30%glycerol.
STORAGE      Store at 4° C for frequent use. Reconstituted antibody can also be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
REFERENCE     
1.  Molecular identification of a putative human hyaluronan synthase. Watanabe K., Yamaguchi Y.
J. Biol. Chem. 271:22945-22948(1996)
2.  PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement.  Morerio C., Rapella A., Rosanda C., Tassano E., Gambini C., Romagnoli G., Panarello C.   Cancer Genet. Cytogenet. 156:183-184(2005)

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