Polyclonal antibody- Human TNFAIP3


  • Model: PA-RA-90005
  • 20 Units in Stock
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Polyclonal antibody- Human TNFAIP3
Size: 0.2ml (200ug/ml)
Storage: -20° C
Immunogen: Synthetic peptide-KLH
Ig type: rabbit IgG
Tumor necrosis factor, alpha-induced protein 3(TNFAIP3) is a protein that in humans is encoded by the TNFAIP3 gene. This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). TNFAIP3 is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses. (http://www.pierce-antibodies.com/).It is a essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. 
Anti-TNFAIP3 antibody is a rabbit polyclonal antibody raised against human TNFAIP3. This antibody has been selected for its ability to recognize human TNFAIP3 in immunohistochemiscal staining, non cross-reactive with other members of the family. 
APPLICATION   Immunocytochemistry in formalin fixed cells:  1:100-500
                   Immunohistochemistry in formalin fixed frozen section:  1:100-500
Immunohistochemistry  in paraffin section:  1:50-200
Optimal working dilutions must be determined by end user.                                                                                                                                                             
CONTENTS     0.1M PBS, 30%glycerol.
STORAGE      Store at 4° C for frequent use. Reconstituted antibody can also be aliquotted and stored frozen at -20° C to -70° C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
1.    Lee EG, Boone DL, Chai S, et al. (2000). "Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.". Science 289 (5488): 2350–4.   
2.    He KL, Ting AT (2002). "A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells.". Mol. Cell. Biol. 22 (17): 6034–45.


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